Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ADORA3. AA range:255-304
Specificity
Adenosine A3-R Polyclonal Antibody detects endogenous levels of Adenosine A3-R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014],
Function
function:Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.,PTM:Phosphorylation on Ser-317 may be crucial for rapid desensitization.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Adenosine receptor A3
Abbreviation
Adenosine A3-R
Other name
ADORA3; Adenosine receptor A3
Human protein sequence Database
P33765
Mouse protein sequence database
Q61618
Rat protein sequence database
P28647
Cellular localization
plasma membrane,integral component of membrane,
Tissue expression
Adrenal gland,Brain,Heart,Lung,Testis,
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