Molecular weight (DA)
110kD
Immunogen
The antiserum was produced against synthesized peptide derived from human EPHA10. AA range:431-480
Specificity
EphA10 Polyclonal Antibody detects endogenous levels of EphA10 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008],
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Mainly expressed in testis.,
Protein name
Ephrin type-A receptor 10
Other name
EPHA10; Ephrin type-A receptor 10
Human protein sequence Database
Q5JZY3
Mouse protein sequence database
Q8BYG9
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
Tissue expression
Mainly expressed in testis.
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