Immunogen
The antiserum was produced against synthesized peptide derived from human GALR1. AA range:161-210
Specificity
GALR1 Polyclonal Antibody detects endogenous levels of GALR1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008],
Function
function:Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,PTM:Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Galanin receptor type 1
Other name
GALR1; GALNR; GALNR1; Galanin receptor type 1; GAL1-R; GALR-1
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P47211
Mouse protein sequence database
P56479
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Brain,Melanoma,Small intestine,
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