Molecular weight (DA)
92kD
Immunogen
The antiserum was produced against synthesized peptide derived from human LTK. AA range:206-255
Specificity
LTK Polyclonal Antibody detects endogenous levels of LTK protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
leukocyte receptor tyrosine kinase(LTK) Homo sapiens The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],
Function
alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:The exact function of this protein is not known. It is probably a receptor with a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in non-hematopoietic cell lines and T- and B-cell lines.,
Protein name
Leukocyte tyrosine kinase receptor
Other name
LTK; TYK1; Leukocyte tyrosine kinase receptor; Protein tyrosine kinase 1
Human protein sequence Database
P29376
Mouse protein sequence database
P08923
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Expressed in non-hematopoietic cell lines and T- and B-cell lines.
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