Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MC4R. AA range:281-330
Specificity
MC4-R Polyclonal Antibody detects endogenous levels of MC4-R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010],
Function
disease:Defects in MC4R are a cause of autosomal dominant obesity [MIM:601665].,function:Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.,online information:Melanocortin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with ATRNL1.,tissue specificity:Brain, placental, and gut tissues.,
Protein name
Melanocortin receptor 4
Other name
MC4R; Melanocortin receptor 4; MC4-R
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P32245
Mouse protein sequence database
P56450
Rat protein sequence database
P70596
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Brain, placental, and gut tissues.
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