Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MTR1B. AA range:301-350
Specificity
MEL-1B-R Polyclonal Antibody detects endogenous levels of MEL-1B-R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008],
Function
function:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retina and less in brain and hippocampus.,
Protein name
Melatonin receptor type 1B
Other name
MTNR1B; Melatonin receptor type 1B; Mel-1B-R; Mel1b receptor
Fields
>>Neuroactive ligand-receptor interaction;>>Circadian entrainment
Human protein sequence Database
P49286
Mouse protein sequence database
Q8CIQ6
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed in retina and less in brain and hippocampus.
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