Molecular weight (DA)
86kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SMO. AA range:68-117
Specificity
Smo Polyclonal Antibody detects endogenous levels of Smo protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010],
Function
disease:Defects in SMO are involved in basal cell carcinoma (BCC).,function:G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,
Protein name
Smoothened homolog
Other name
SMO; SMOH; Smoothened homolog; SMO; Protein Gx
Fields
>>Hedgehog signaling pathway;>>Axon guidance;>>Pathways in cancer;>>Proteoglycans in cancer;>>Basal cell carcinoma
Human protein sequence Database
Q99835
Mouse protein sequence database
P56726
Rat protein sequence database
P97698
Cellular localization
Membrane ; Multi-pass membrane protein . Cell projection, cilium .
Tissue expression
Brain,Embryonic lung,Synovial membrane,
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