Molecular weight (DA)
22kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RALA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RAS like proto-oncogene A(RALA) Homo sapiens The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1.,
Protein name
Ras-related protein Ral-A
Fields
>>Ras signaling pathway;>>Rap1 signaling pathway;>>Phospholipase D signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Colorectal cancer;>>Pancreatic cancer
Human protein sequence Database
P11233
Mouse protein sequence database
P63321
Rat protein sequence database
P63322
Cellular localization
Cell membrane ; Lipid-anchor ; Cytoplasmic side. Cleavage furrow . Midbody, Midbody ring . Mitochondrion . Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles (PubMed:19306925). May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214). However, localization at the midbody at late cytokinesis was not confirmed (PubMed:18756269). Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277). .
Tissue expression
Eye,Lung,Platelet,
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