Immunogen
The antiserum was produced against synthesized peptide derived from human CD88/C5aR around the phosphorylation site of Ser338. AA range:301-350
Specificity
Phospho-CD88 (S338) Polyclonal Antibody detects endogenous levels of CD88 protein only when phosphorylated at S338.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.,PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Function
function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.,PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
C5a anaphylatoxin chemotactic receptor
Other name
C5AR1; C5AR; C5R1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD antigen CD88
Fields
>>Neuroactive ligand-receptor interaction;>>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Alcoholic liver disease;>>Staphylococcus aureus infection;>>Coronavirus disease - COVID-19
Human protein sequence Database
P21730
Mouse protein sequence database
P30993
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle . Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. .
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