Molecular weight (DA)
32kD
Immunogen
The antiserum was produced against synthesized peptide derived from human C1QBP. AA range:61-110
Specificity
C1QBP Polyclonal Antibody detects endogenous levels of C1QBP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008],
Function
caution:Was originally (PubMed:1830244 and PubMed:8262387) thought to be a pre-mRNA splicing factor SF2 p32 subunit and to play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.,function:Not known. Binds to the globular "heads" of C1Q thus inhibiting C1 activation.,similarity:Belongs to the MAM33 family.,subunit:Interacts with Rubella virus capsid protein.,
Protein name
Complement component 1 Q subcomponent-binding protein mitochondrial
Other name
C1QBP; GC1QBP; HABP1; SF2P32; Complement component 1 Q subcomponent-binding protein; mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33
Human protein sequence Database
Q07021
Mouse protein sequence database
O35658
Rat protein sequence database
O35796
Cellular localization
Mitochondrion matrix . Nucleus . Nucleus, nucleolus . Cell membrane ; Peripheral membrane protein ; Extracellular side. Secreted. Cytoplasm . Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes. Localizes to the nucleolus when coexpressed with POLGARF (PubMed:32958672). Interaction with POLGARF is likely to result in prevention of C1QBP maturation and redirection from mitochondria to nucleoli (PubMed:32958672). .
Tissue expression
Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells.
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