Molecular weight (DA)
53kD
Immunogen
The antiserum was produced against synthesized peptide derived from human LILRA1. AA range:53-102
Specificity
LIR-6 Polyclonal Antibody detects endogenous levels of LIR-6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],
Function
function:May act as receptor for class I MHC antigens.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in monocytes and B-cells.,
Protein name
Leukocyte immunoglobulin-like receptor subfamily A member 1
Other name
LILRA1; LIR6; Leukocyte immunoglobulin-like receptor subfamily A member 1; CD85 antigen-like family member I; Leukocyte immunoglobulin-like receptor 6; LIR-6; CD antigen CD85i
Fields
>>Osteoclast differentiation;>>B cell receptor signaling pathway
Human protein sequence Database
O75019
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
Detected in monocytes and B-cells.
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