Immunogen
The antiserum was produced against synthesized peptide derived from human NKTR. AA range:784-833
Specificity
NK-TR Polyclonal Antibody detects endogenous levels of NK-TR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,function:Component of a putative tumor-recognition complex. Involved in the function of NK cells.,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Attached to the membrane via its N-terminus.,
Protein name
NK-tumor recognition protein
Other name
NKTR; NK-tumor recognition protein; NK-TR protein; Natural-killer cells cyclophilin-related protein
Human protein sequence Database
P30414
Mouse protein sequence database
P30415
Rat protein sequence database
Cellular localization
Cell membrane .
Tissue expression
Aorta endothelial cell,Blood,Epithelium,Fetal kidney,Human endometr
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