Molecular weight (DA)
27kD
Immunogen
Synthetic peptide from human protein at AA range: 21-70
Specificity
The antibody detects endogenous MBL-C protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008],
Function
disease:Genetic variations in MBL2 are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,disease:There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.,function:Binds mannose and N-acetylglucosamine in a calcium-dependent manner. Is capable of host defense against pathogens, by activating the classical complement pathway independently of the antibody.,online information:Mannose-binding protein,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 colla
Gene Name
MBL2 COLEC1 MBL
Protein name
mannose-binding lectin (protein C) 2, soluble (opsonic defect)
Other name
MBL2 COLEC1 MBL
Fields
>>Phagosome;>>Complement and coagulation cascades;>>Staphylococcus aureus infection;>>Coronavirus disease - COVID-19
Human protein sequence Database
P11226
Mouse protein sequence database
P41317
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Plasma protein produced mainly in the liver.
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