Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from Dyrk4 . at AA range: 350-430
Specificity
Dyrk4 Polyclonal Antibody detects endogenous levels of Dyrk4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Possible non-essential role in spermiogenesis.,PTM:Autophosphorylated on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,
Protein name
Dual specificity tyrosine-phosphorylation-regulated kinase 4
Other name
DYRK4; Dual specificity tyrosine-phosphorylation-regulated kinase 4
Human protein sequence Database
Q9NR20
Mouse protein sequence database
Q8BI55
Rat protein sequence database
Cellular localization
[Isoform 1]: Cytoplasm .; [Isoform 4]: Cytoplasm . Nucleus .
Tissue expression
Brain,Kidney,Lung,Testis,
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