Immunogen
Purified recombinant fragment of human Fucokinase expressed in E. Coli.
Specificity
Fucokinase Monoclonal Antibody detects endogenous levels of Fucokinase protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
fucokinase(FUK) Homo sapiens The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.,function:Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.,similarity:Belongs to the GHMP kinase family.,
Protein name
L-fucose kinase
Other name
FUK; L-fucose kinase; Fucokinase
Fields
>>Fructose and mannose metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of nucleotide sugars
Human protein sequence Database
Q8N0W3
Mouse protein sequence database
Rat protein sequence database
Cellular localization
cytoplasm,cytosol,
Tissue expression
Expressed in fibroblasts.
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