Molecular weight (DA)
57kD
Immunogen
Synthesized peptide derived from human DELE1
Specificity
This antibody detects endogenous levels of DELE1 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
[DAP3-binding cell death enhancer 1]: Key activator of the integrated stress response (ISR) following mitochondrial stress . In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR . Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation . ; [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI . It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein
Protein name
Death ligand signal enhancer
Human protein sequence Database
Q14154
Mouse protein sequence database
Q9DCV6
Rat protein sequence database
P60924
Cellular localization
[DAP3-binding cell death enhancer 1]: Mitochondrion . Mitochondrion inner membrane . Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1). .; [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol . This short form is generated by proteolytic processing by OMA1 in response to mitochondrial stress, leading to translocation to the cytosol. .
Tissue expression
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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