Molecular weight (DA)
47kD
Immunogen
Purified recombinant human CKMT2 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of CKMT2 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
creatine kinase, mitochondrial 2(CKMT2) Homo sapiens Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gen
Function
catalytic activity:ATP + creatine = ADP + phosphocreatine.,function:Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.,miscellaneous:Mitochondrial creatine kinase binds cardiolipin.,similarity:Belongs to the ATP:guanido phosphotransferase family.,subunit:Exists as an octamer composed of four CKMT2 homodimers.,tissue specificity:Sarcomere-specific. Found only in heart and skeletal muscles.,
Other name
CKMT 2;Basic-type mitochondrial creatine kinase;CKMT 2;CKMT2;CPK;Creatine kinase mitochondrial 2;Creatine kinase mitochondrial 2 (sarcomeric);Creatine kinase S-type; creatine kinase S-type, mitochondrial;KCRS_HUMAN;Mib CK;Mib-CK;mitochondrial; OTTHUMP00000147542;S-MtCK;Sarcomeric mitochondrial creatine kinase;SMTCK.
Fields
>>Arginine and proline metabolism;>>Metabolic pathways
Human protein sequence Database
P17540
Mouse protein sequence database
Q6P8J7
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Tissue expression
Sarcomere-specific. Found only in heart and skeletal muscles.
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