Molecular weight (DA)
62kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GRK7. AA range:371-420
Specificity
GRK 7 Polyclonal Antibody detects endogenous levels of GRK 7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Phosphorylates cone opsins thereby initiating their deactivation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Retina. Cones and rod.,
Protein name
G protein-coupled receptor kinase 7
Other name
GRK7; GPRK7; G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7
Fields
>>Chemokine signaling pathway;>>Endocytosis;>>Phototransduction
Human protein sequence Database
Q8WTQ7
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane ; Lipid-anchor .
Tissue expression
Retinal cones, outer and inner segments.
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