Molecular weight (DA)
47kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GSK3B. AA range:1-50
Specificity
GSK3β Polyclonal Antibody detects endogenous levels of GSK3β protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
Function
catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate
Protein name
Glycogen synthase kinase-3 beta
Other name
GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>ErbB signaling pathway;>>Chemokine signaling pathway;>>Cell cycle;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>Wnt signaling pathway;>>Hedgehog signaling pathway;>>Axon guidance;>>Hippo signaling pathway;>>Focal adhesion;>>Signaling pathways regulating pluripotency of stem cells;>>IL-17 signaling pathway;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>Neurotrophin signaling pathway;>>Dopaminergic synapse;>>Insulin signaling pathway;>>Melanogenesis;>>Prolactin signaling pathway;>>Thyroid hormone signaling pathway;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Cushing syndrome;>>Growth hormone synthesis, secretion and action;>>Alcoholic liver disease;>>Alzheimer disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Yersinia infection;>>Hepatitis C;>>Measles;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpes
Human protein sequence Database
P49841
Mouse protein sequence database
Q9WV60
Rat protein sequence database
P18266
Cellular localization
Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
Tissue expression
Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
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