Immunogen
The antiserum was produced against synthesized peptide derived from human CDKN2D. AA range:96-145
Specificity
p19 Polyclonal Antibody detects endogenous levels of p19 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008],
Function
function:Interacts strongly with CDK4 and CDK6 and inhibits them.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,
Protein name
Cyclin-dependent kinase 4 inhibitor D
Other name
CDKN2D; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d
Fields
>>FoxO signaling pathway;>>Cell cycle
Human protein sequence Database
P55273
Mouse protein sequence database
Q60773
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Bone marrow,Muscle,Platelet,Thymus,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车