Immunogen
The antiserum was produced against synthesized peptide derived from human MAP3K9. AA range:561-610
Specificity
MLK1 Polyclonal Antibody detects endogenous levels of MLK1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include retroperitoneal neuroblastoma. Among its related pathways are MAP Kinase Signaling andTGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1.
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.,
Protein name
Mitogen-activated protein kinase kinase kinase 9
Other name
MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1
Human protein sequence Database
P80192
Mouse protein sequence database
Q3U1V8
Rat protein sequence database
Cellular localization
intracellular,integral component of membrane,
Tissue expression
Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
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