Molecular weight (DA)
85kD
Immunogen
The antiserum was produced against synthesized peptide derived from human K6PL. AA range:691-740
Specificity
PFK-B Polyclonal Antibody detects endogenous levels of PFK-B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],
Function
catalytic activity:ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.,cofactor:Magnesium.,enzyme regulation:Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate.,miscellaneous:In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.,similarity:Belongs to the phosphofructokinase family. Two domains subfamily.,subunit:Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3.,
Protein name
6-phosphofructokinase liver type
Other name
PFKL; 6-phosphofructokinase; liver type; Phosphofructo-1-kinase isozyme B; PFK-B; Phosphofructokinase 1; Phosphohexokinase
Fields
>>Glycolysis / Gluconeogenesis;>>Pentose phosphate pathway;>>Fructose and mannose metabolism;>>Galactose metabolism;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids;>>RNA degradation;>>HIF-1 signaling pathway;>>AMPK signaling pathway;>>Thyroid hormone signaling pathway;>>Glucagon signaling pathway;>>Central carbon metabolism in cancer
Human protein sequence Database
P17858
Mouse protein sequence database
P12382
Rat protein sequence database
P30835
Cellular localization
Cytoplasm .
Tissue expression
Brain,Cervix,Colon,Human amygdala,Human retina,Kidney,Liver,Lung,Muscle,Pla
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