Molecular weight (DA)
195kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SGK269. AA range:111-160
Specificity
SgK269 Polyclonal Antibody detects endogenous levels of SgK269 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014],
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
Protein name
Pseudopodium-enriched atypical kinase 1
Other name
PEAK1; KIAA2002; Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269
Human protein sequence Database
Q9H792
Mouse protein sequence database
Q69Z38
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Colocalizes with F-actin in serum-rich medium (PubMed:20534451). Actin colocalization is reduced during serum starvation (PubMed:20534451). .
Tissue expression
Brain,Epithelium,Lung,Mesangial cell,Smooth muscle,Spleen,
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