Molecular weight (DA)
139kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ALPK1. AA range:11-60
Specificity
α-protein Kinase 1 Polyclonal Antibody detects endogenous levels of α-protein Kinase 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Function
function:Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.,similarity:Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.,similarity:Contains 1 alpha-type protein kinase domain.,tissue specificity:Highly expressed in liver.,
Protein name
Alpha-protein kinase 1
Abbreviation
α-protein Kinase 1
Other name
ALPK1; KIAA1527; LAK; Alpha-protein kinase 1; Chromosome 4 kinase; Lymphocyte alpha-protein kinase
Human protein sequence Database
Q96QP1
Mouse protein sequence database
Q9CXB8
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell projection, cilium . Localized at the base of primary cilia. .
Tissue expression
Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina (PubMed:30967659).
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