Immunogen
Synthesized peptide derived from human AMPKβ2 AA range: 130-210
Specificity
This antibody detects endogenous levels of Human AMPKβ2
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit.,PTM:Phosphorylated when associated with the catalytic subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits.,
Function
fatty acid metabolic process, fatty acid biosynthetic process, lipid biosynthetic process, regulation of cellular ketone metabolic process, organic acid biosynthetic process, regulation of lipid metabolic process, regulation of fatty acid metabolic process, regulation of fatty acid oxidation, carboxylic acid biosynthetic process,
Other name
5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)
Fields
>>FoxO signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Apelin signaling pathway;>>Tight junction;>>Circadian rhythm;>>Thermogenesis;>>Insulin signaling pathway;>>Adipocytokine signaling pathway;>>Oxytocin signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Alcoholic liver disease;>>Hypertrophic cardiomyopathy
Human protein sequence Database
O43741
Mouse protein sequence database
Q6PAM0
Rat protein sequence database
Q9QZH4
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