Immunogen
Synthesized peptide derived from human CD23
Specificity
This antibody detects endogenous levels of human CD23. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
Function
function:This receptor has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).,miscellaneous:There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.,online information:CD23,PTM:N- and O-glycosylated.,similarity:Contains 1 C-type lectin domain.,subcellular location:Also exists as a soluble excreted form.,
Gene Name
FCER2 CD23A CLEC4J FCE2 IGEBF
Protein name
Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleav
Fields
>>Hematopoietic cell lineage;>>Epstein-Barr virus infection
Human protein sequence Database
P06734
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Also exists as a soluble excreted form, sCD23.
Tissue expression
B-cell,Blood,
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