Immunogen
Synthesized peptide derived from human hCG
Specificity
This antibody detects endogenous levels of human hCG. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
Source
Mouse, Monoclonal/IgG2a, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500, WB 1:200-1000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
Function
online information:Proteic grace - Issue 77 of December 2006,similarity:Belongs to the glycoprotein hormones subunit alpha family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,
Protein name
Glycoprotein hormones alpha chain (Anterior pituitary glycoprotein hormones common subunit alpha) (Choriogonadotropin alpha chain) (Chorionic gonadotrophin subunit alpha) (CG-alpha) (Follicle-stimulat
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>GnRH signaling pathway;>>Ovarian steroidogenesis;>>Prolactin signaling pathway;>>Thyroid hormone synthesis;>>Regulation of lipolysis in adipocytes;>>GnRH secretion;>>Autoimmune thyroid disease
Human protein sequence Database
P01215
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Pituitary,Placenta,
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