Immunogen
Synthesized peptide derived from human PD-1
Specificity
This antibody detects endogenous levels of human PD-1. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500, WB 1:200-1000;IF/ICC 1:100-500
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
Function
developmental stage:Induced at programmed cell death.,disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
Protein name
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Fields
>>Cell adhesion molecules;>>T cell receptor signaling pathway;>>PD-L1 expression and PD-1 checkpoint pathway in cancer
Human protein sequence Database
Q15116
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein.
Tissue expression
Placenta,Pooled tissue,Uterine cervix,
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