Immunogen
Synthesized peptide derived from human Thyroid-Stimulating Hormone(TSH)
Specificity
This antibody detects endogenous levels of human Thyroid-Stimulating Hormone(TSH). Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in para
Source
Mouse, Monoclonal/IgG1, Lambda
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 500-2000 IHC-p 1:100-500. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013],
Function
function:Indispensable for the control of thyroid structure and metabolism.,online information:Clinical information on Thyrogen,online information:Thyroid-stimulating hormone entry,pharmaceutical:Available under the name Thyrogen (Genzyme). Used in combination with other tests to detect recurring or leftover thyroid cancer cells in patients with a history of certain types of thyroid cancer.,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,
Protein name
Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (Thyrotropin alfa)
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Thyroid hormone synthesis;>>Regulation of lipolysis in adipocytes;>>Autoimmune thyroid disease
Human protein sequence Database
P01222
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
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