Immunogen
Synthesized peptide derived from human CD38
Specificity
This antibody detects endogenous levels of human CD38. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500, WB 1:200-1000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Function
catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.,
Protein name
ADP-ribosyl cyclase 1 (EC 3.2.2.5) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38)
Fields
>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Hematopoietic cell lineage;>>Oxytocin signaling pathway;>>Salivary secretion;>>Pancreatic secretion
Human protein sequence Database
P28907
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane; Single-pass type II membrane protein.
Tissue expression
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
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