Immunogen
Synthesized peptide derived from human Glial Fibrillary Acidic Protein (GFAP)
Specificity
This antibody detects endogenous levels of human Glial Fibrillary Acidic Protein (GFAP). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in par
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500, WB 1:200-1000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],
Function
alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-spe
Protein name
Glial fibrillary acidic protein (GFAP)
Fields
>>JAK-STAT signaling pathway
Human protein sequence Database
P14136
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Associated with intermediate filaments. .
Tissue expression
Expressed in cells lacking fibronectin.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车