Immunogen
Synthesized peptide derived from human Mart-1/Melan-A
Specificity
This antibody detects endogenous levels of human Mart-1/Melan-A. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section
Source
Mouse, Monoclonal/IgG2b, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:300-500. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
Function
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
Protein name
Mart-1/Melan-A
Other name
Melanoma antigen recognized by T-cells 1 (MART-1;Antigen LB39-AA;Antigen SK29-AA;Protein Melan-A)
Human protein sequence Database
Q16655
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Tissue expression
Expression is restricted to melanoma and melanocyte cell lines and retina.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车