Immunogen
Synthesized peptide derived from human CD20
Specificity
This antibody detects endogenous levels of CD20 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:10. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Function
caution:Epitope 1, mapped in PubMed:16785532, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained.,function:This protein may be involved in the regulation of B-cell activation and proliferation.,online information:CD20 entry,pharmaceutical:Monoclonal antibodies(mAb) against CD20 are used to treat B-cell non-Hodgkin's lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity.,PTM:Phosphorylated. Might be functionally regulated by protein kinase(s).,similarity:Belongs to the MS4A family.,tissue specificity:Expressed on B-cells.,
Other name
B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1;Bp35;Leukocyte surface antigen Leu-16;Membrane-spanning 4-domains subfamily A member 1;CD antigen CD20)
Fields
>>Hematopoietic cell lineage
Human protein sequence Database
P11836
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell membrane ; Lipid-anchor . Constitutively associated with membrane rafts. .
Tissue expression
Expressed on B-cells.
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