Immunogen
Synthesized peptide derived from human Cytokeratin 20 (CK20)
Specificity
This antibody detects endogenous levels of Cytokeratin 20 (CK20) at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Function
developmental stage:First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative.,function:Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during t
Protein name
Cytokeratin 20 (CK20)
Abbreviation
Cytokeratin 20
Other name
Keratin, type I cytoskeletal 20 (Cytokeratin-20;CK-20;Keratin-20;K20;Protein IT)
Fields
>>Estrogen signaling pathway;>>Staphylococcus aureus infection
Human protein sequence Database
P35900
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
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