Immunogen
Synthesized peptide derived from human Factor XIIIa
Specificity
This antibody detects endogenous levels of Factor XIIIa at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:400. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Function
catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,disease:Defects in F13A1 are the cause of F13A deficiency [MIM:134570]. F13A deficiency is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. In addition to the common presentation such as subcutaneous and intramuscular haematomas, severe bleeding such as intracranial hemorrhages may occur.,function:Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.,online information:Factor XIII entry,online information:The Singapore human
Protein name
Factor XIIIa
Abbreviation
Factor XIIIa
Other name
Coagulation factor XIII A chain (Coagulation factor XIIIa;EC 2.3.2.13;Protein-glutamine gamma-glutamyltransferase A chain;Transglutaminase A chain)
Fields
>>Complement and coagulation cascades;>>Coronavirus disease - COVID-19
Human protein sequence Database
P00488
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm. Secreted . Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Tissue expression
Brain,Pancreas,Plasma,
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