Immunogen
Synthesized peptide derived from human Oct-2
Specificity
The antibody can specifically recognize human Oct-2 protein.
Source
Mouse, Monoclonal/IgG2b, kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.74% sodium azide.
Dilution rate
IHC-p 1:100-500, IF 1:100-500
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Function
function:Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.,similarity:Belongs to the POU transcription factor family. Class-2 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subunit:Interacts with NR3C1, AR and PGR.,tissue specificity:Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147.,
Gene Name
POU2F2 OCT2 OTF2
Other name
POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2;Octamer-binding protein 2;Oct-2;Octamer-binding transcription factor 2;OTF-2)
Fields
>>Herpes simplex virus 1 infection;>>Lipid and atherosclerosis
Human protein sequence Database
P09086
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus.
Tissue expression
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
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