Immunogen
Synthesized peptide derived from human Melan-A
Specificity
The antibody can specifically recognize human Melan-A protein.
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.170% sodium azide.
Dilution rate
IHC-p 1:100-500, IF 1:100-500
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Function
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
Other name
Melanoma antigen recognized by T-cells 1 (MART-1;Antigen LB39-AA;Antigen SK29-AA;Protein Melan-A)
Human protein sequence Database
Q16655
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Tissue expression
Expression is restricted to melanoma and melanocyte cell lines and retina.
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