Immunogen
Synthesized peptide derived from human p120 Catenin
Specificity
The antibody can specifically recognize human p120 catenin protein. In western blotting of Hela, A431 and HEK293 cell lysates, the antibody can label a band with molecular weight around 100~110 kDa.
Source
Monoclonal Mouse IgG2b, Kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400,WB: 500-1000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
catenin delta 1(CTNND1) Homo sapiens This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010],
Function
alternative products:Experimental confirmation may be lacking for some isoforms,disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.,domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.,function:Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound clo
Gene Name
CTNND1 KIAA0384
Protein name
Cadherin associated Src substrate;Cadherin-associated Src substrate;CAS;Catenin (cadherin associated protein) delta 1;Catenin delta 1;Catenin delta;Catenin delta-1;CTND1_HUMAN;CTNND 1;CTNND;CTNND1;del
Abbreviation
p120 Catenin
Other name
Cadherin associated Src substrate;Cadherin-associated Src substrate;CAS;Catenin (cadherin associated protein) delta 1;Catenin delta 1;Catenin delta;Catenin delta-1;CTND1_HUMAN;CTNND 1;CTNND;CTNND1;delta 1 Catenin;KIAA0384;p120;P120 CAS;p120 catenin;P120 CTN;p120(cas);p120(ctn);P120CAS;P120CTN
Fields
>>Rap1 signaling pathway;>>Adherens junction;>>Leukocyte transendothelial migration
Human protein sequence Database
O60716
Mouse protein sequence database
P30999
Rat protein sequence database
Cellular localization
Cytoplasmic, Membranous
Tissue expression
Breast/ Tonsil
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