Immunogen
Synthesized peptide derived from human PSM AA range: 571-620
Specificity
This antibody detects endogenous levels of Human PSM
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Gene Name
FOLH1 FOLH NAALAD1 PSM PSMA GIG27
Other name
Glutamate carboxypeptidase 2 (EC 3.4.17.21;Cell growth-inhibiting gene 27 protein;Folate hydrolase 1;Folylpoly-gamma-glutamate carboxypeptidase;FGCP;Glutamate carboxypeptidase II;GCPII;Membrane glutamate carboxypeptidase;mGCP;N-acetylated-alpha-linked acidic dipeptidase I;NAALADase I;Prostate-specific membrane antigen;PSM;PSMA;Pteroylpoly-gamma-glutamate carboxypeptidase)
Fields
>>Alanine, aspartate and glutamate metabolism;>>Metabolic pathways;>>Vitamin digestion and absorption
Human protein sequence Database
Q04609
Mouse protein sequence database
O35409
Rat protein sequence database
P70627
Cellular localization
Cell membrane ; Single-pass type II membrane protein .; [Isoform PSMA']: Cytoplasm .
Tissue expression
Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.
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