Molecular weight (DA)
32kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HOXD8. AA range:241-290
Specificity
HoxD8 Polyclonal Antibody detects endogenous levels of HoxD8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010],
Function
function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.,similarity:Belongs to the Antp homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
Protein name
Homeobox protein Hox-D8
Other name
HOXD8; HOX4E; Homeobox protein Hox-D8; Homeobox protein Hox-4E; Homeobox protein Hox-5.4
Human protein sequence Database
P13378
Mouse protein sequence database
P23463
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Kidney,Peripheral Nervous System,
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