Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Pax-1. AA range:318-367
Specificity
Pax-1 Polyclonal Antibody detects endogenous levels of Pax-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012],
Function
function:This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.,similarity:Contains 1 paired domain.,
Protein name
Paired box protein Pax-1
Other name
PAX1; HUP48; Paired box protein Pax-1; HuP48
Human protein sequence Database
P15863
Mouse protein sequence database
P09084
Rat protein sequence database
Cellular localization
Nucleus.
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