Molecular weight (DA)
16 22kD
Immunogen
Synthesized peptide derived from human EFNA1 (Cleaved-Ser182)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat EFNA1 (Cleaved-Ser182, protein was cleaved amino acid sequence between 182-183 )
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
induction:By TNF-alpha and interleukin-1 beta.,similarity:Belongs to the ephrin family.,subunit:Binds to the receptor tyrosine kinases EPHA2, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.,
Function
MAPKKK cascade, activation of MAPK activity, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade,protein kinase cascade, cell-cell signaling, regulation of cell morphogenesis involved in differentiation, regulation of neuron projection development, phosphorylation, regulation of phosphate metabolic process, regulation of cell morphogenesis, neuron differentiation, regulation of cell projection organization, positive regulation of kinase activity,regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of mol
Gene Name
EFNA1 EPLG1 LERK1 TNFAIP4
Protein name
EFNA1 (Cleaved-Ser182)
Other name
Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1;LERK-1;Immediate early response protein B61;Tumor necrosis factor alpha-induced protein 4;TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>PI3K-Akt signaling pathway;>>Axon guidance;>>MicroRNAs in cancer
Human protein sequence Database
P20827
Mouse protein sequence database
P52793
Rat protein sequence database
P97553
Cellular localization
Cell membrane ; Lipid-anchor, GPI-anchor .; [Ephrin-A1, secreted form]: Secreted .
Tissue expression
Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
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