Molecular weight (DA)
20kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FGF22. AA range:71-120
Specificity
FGF-22 Polyclonal Antibody detects endogenous levels of FGF-22 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Function
function:May be involved in hair development.,similarity:Belongs to the heparin-binding growth factors family.,subunit:Interacts with FGFBP1.,
Protein name
Fibroblast growth factor 22
Other name
FGF22; Fibroblast growth factor 22; FGF-22
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Regulation of actin cytoskeleton;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Melanoma;>>Breast cancer;>>Gastric cancer
Human protein sequence Database
Q9HCT0
Mouse protein sequence database
Q9ESS2
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Placenta,
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