Molecular weight (DA)
57kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GDF-9. AA range:273-322
Specificity
GDF-9 Polyclonal Antibody detects endogenous levels of GDF-9 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins. [provided by RefSeq, Jul 2016],
Function
function:Required for ovarian folliculogenesis.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.,
Protein name
Growth/differentiation factor 9
Other name
GDF9; Growth/differentiation factor 9; GDF-9
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
O60383
Mouse protein sequence database
Q07105
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).
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