Molecular weight (DA)
26kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IL-32. AA range:177-226
Specificity
IL-32 Polyclonal Antibody detects endogenous levels of IL-32 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.,induction:Expression increased after activation of T-cells by mitogens or activation of NK cells by IL-2.,tissue specificity:Selectively expressed in lymphocytes. Expression more prominent in immunce cells than in non-immune cells.,
Protein name
Interleukin-32
Other name
IL32; NK4; TAIF; Interleukin-32; IL-32; Natural killer cells protein 4; Tumor necrosis factor alpha-inducing factor
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
P24001
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells.
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