Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from the N-terminal region of human IL-4I1.
Specificity
IL-4I1 Polyclonal Antibody detects endogenous levels of IL-4I1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
Function
catalytic activity:An L-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).,cofactor:FAD.,function:Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation.,induction:By interleukin-4.,similarity:Belongs to the flavin monoamine oxidase family. FIG1 subfamily.,tissue specificity:Primarily found in immune tissues (isoform 1).,
Protein name
L-amino-acid oxidase
Other name
IL4I1; FIG1; L-amino-acid oxidase; LAAO; LAO; Interleukin-4-induced protein 1; IL4-induced protein 1; Protein Fig-1; hFIG1
Fields
>>Alanine, aspartate and glutamate metabolism;>>Cysteine and methionine metabolism;>>Valine, leucine and isoleucine degradation;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Tryptophan metabolism;>>Phenylalanine, tyrosine and tryptophan biosynthesis;>>Metabolic pathways
Human protein sequence Database
Q96RQ9
Mouse protein sequence database
O09046
Rat protein sequence database
Cellular localization
Secreted . Lysosome . Cytoplasmic vesicle, secretory vesicle, acrosome . Secreted at the immunological synapse. .
Tissue expression
Primarily found in immune tissues, with the highest expression in lymph nodes and spleen (PubMed:12031486, PubMed:12446450). Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein level) (PubMed:17356132). Also present in spermatozoa (at protein level) (PubMed:25767141). Highly expressed in primary mediastinal large B-cell lymphoma, a specific subtype of diffuse large B-cell lymphoma (PubMed:12446450). Expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages (PubMed:19436310).
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