Molecular weight (DA)
19kD
Immunogen
The antiserum was produced against synthesized peptide derived from human INSL4. AA range:41-90
Specificity
INSL4 Polyclonal Antibody detects endogenous levels of INSL4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008],
Function
developmental stage:Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblast is different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments.,function:May play an important role in trophoblast development and in the regulation of bone formation.,similarity:Belongs to the insulin family.,tissue specificity:Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.,
Protein name
Early placenta insulin-like peptide
Other name
INSL4; Early placenta insulin-like peptide; EPIL; Insulin-like peptide 4; Placentin
Human protein sequence Database
Q14641
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.
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