Molecular weight (DA)
10kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TGF alpha. AA range:111-160
Specificity
TGFα Polyclonal Antibody detects endogenous levels of TGFα protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
Function
function:TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.,similarity:Contains 1 EGF-like domain.,subunit:Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2.,
Protein name
Protransforming growth factor alpha
Other name
TGFA; Protransforming growth factor alpha
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>MAPK signaling pathway;>>ErbB signaling pathway;>>Ras signaling pathway;>>PI3K-Akt signaling pathway;>>Estrogen signaling pathway;>>Pathways in cancer;>>Colorectal cancer;>>Renal cell carcinoma;>>Pancreatic cancer;>>Glioma;>>Prostate cancer;>>Non-small cell lung cancer;>>Hepatocellular carcinoma
Human protein sequence Database
P01135
Mouse protein sequence database
P48030
Rat protein sequence database
P01134
Cellular localization
[Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
Tissue expression
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车