Molecular weight (DA)
21kD
Immunogen
The antiserum was produced against synthesized peptide derived from human VEGFB. AA range:91-140
Specificity
VEGF-B Polyclonal Antibody detects endogenous levels of VEGF-B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011],
Function
alternative products:Additional isoforms seem to exist,function:Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.,PTM:VEGF-B186 is O-glycosylated.,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.,subunit:Homodimer; disulfide-linked. Can also form heterodimer with VEGF.,tissue specificity:Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.,
Protein name
Vascular endothelial growth factor B
Other name
VEGFB; VRF; Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Pathways in cancer
Human protein sequence Database
P49765
Mouse protein sequence database
P49766
Rat protein sequence database
O35485
Cellular localization
Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Tissue expression
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
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