Molecular weight (DA)
53kD
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human SCG3. AA range:21-70
Specificity
Sg III Polyclonal Antibody detects endogenous levels of Sg III protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
secretogranin III(SCG3) Homo sapiens The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
Function
subcellular location:Neuroendocrine and endocrine secretory granules.,tissue specificity:Expressed in brain, heart, kidney, liver and skeletal muscle.,
Protein name
Secretogranin-3
Other name
SCG3; Secretogranin-3; Secretogranin III; SgIII
Human protein sequence Database
Q8WXD2
Mouse protein sequence database
P47867
Rat protein sequence database
P47868
Cellular localization
Cytoplasmic vesicle, secretory vesicle . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Secreted . Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts. .
Tissue expression
Expressed in brain, heart, kidney, liver and skeletal muscle.
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